ALIMTA PACKAGE INSERT PDF

ALIMTA (pemetrexed for injection) [package insert]. Indianapolis, IN: Eli Lilly and Company; Langer CJ, et al. Lancet Oncol. ;17(11) Learn how ALIMTA may help treat advanced nonsquamous non-small cell lung cancer. ALIMTA and carboplatin (carbo) is approved by the FDA to be used with an the FDA in combination with carboplatin (another chemotherapy drug) and. Read all of this leaflet carefully before you start receiving this medicine because it contains important information for you. -. Keep this leaflet. You may need to.

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The risk of myelosuppression is increased in patients who do not receive vitamin supplementation. Eli Lilly and Company; Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Indications and Important Safety Information. Advise pregnant women of the potential risk to the fetus. ALIMTA is indicated as a single agent for the maintenance treatment of patients with locally advanced or metastatic nonsquamous non-small cell lung cancer NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy.

ALIMTA® (Pemetrexed) and Pharmacokinetics

Scagliotti GV, et al. Advise males with female partners of reproductive potential to use effective contraception during treatment with ALIMTA and for 3 months after the final packsge.

It is very important to take folic acid by mouth and receive vitamin B 12 injections from your healthcare provider during your treatment with ALIMTA to lower your risk of harmful side effects. There is no information regarding the presence of pemetrexed or its metabolites in human milk, the effects on the breastfed infant, or the effects on milk production. Radiation recall is a skin reaction that can happen in people who have received radiation treatment in the past and are treated with ALIMTA.

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If you are allergic to pemetrexed, tell your doctor because you should not receive it. Adverse reactions observed in pediatric patients studied were similar to those observed in adults. Langer CJ, et al. Tell your healthcare provider right away if you have a decrease in amount of urine. You are encouraged to report negative side effects of prescription drugs to the FDA.

ALIMTA® (pemetrexed): Storage of Unreconstituted Vials

ALIMTA can cause severe myelosuppression resulting in a requirement for transfusions and which may lead to neutropenic infection. Patients with Renal Impairment: Tell your xlimta provider right away if you get any new or worsening symptoms of shortness of breath, cough, or fever.

Low blood cell counts.

To view the most recent and complete version of the guidelines, go online to NCCN. It is not known if these effects are reversible.

Ibuprofen increases exposure AUC of pemetrexed. If concomitant ibuprofen use cannot be avoided, monitor patients more frequently for ALIMTA adverse reactions, including myelosuppression, renal, and gastrointestinal toxicity. Severe vomiting or diarrhea can lead to loss of fluids dehydration alinta may cause kidney problems to become worse. Talk to your healthcare provider if this is a concern for you.

Low blood cell counts can be severe, including low white blood cell counts neutropenialow platelet counts thrombocytopeniaand low red blood cell counts anemia.

The infusion is given over 10 minutes. Kidney problems, including kidney failure. Based on high-level evidence eg, lackage controlled trials and there is uniform NCCN consensus that the intervention is appropriate.

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ALIMTA® (Pemetrexed) and Pharmacokinetics

Advise females of reproductive potential to use effective contraception during treatment with ALIMTA and for 6 months after the final dose. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Obtain a complete blood count at the beginning of each cycle. The incidences of Grade anemia, fatigue, thrombocytopenia, hypertension, and neutropenia were higher in patients 65 years of age and older as compared to younger patients: Tell your healthcare provider right away if you develop blisters, skin sores, skin peeling, or painful sores, or ulcers in your packsge, nose, throat or genital area.

This indication is approved under accelerated approval based on tumor response rate and progression-free survival. NCCN makes no warranties of any kind whatsoever regarding their content, use, or application and disclaims any responsibility for their application or use in any way. Your healthcare provider may change your dose of ALIMTA, delay treatment, or stop treatment if you have certain side effects.

Tell your healthcare provider if you get swelling, blistering, or a rash that looks like a sunburn in an area that was previously treated with radiation. For more information, ask your healthcare provider or pharmacist. ALIMTA is indicated, in combination with cisplatin, for the initial treatment of patients with malignant pleural mesothelioma MPM whose disease is unresectable or who are otherwise not candidates for curative surgery.