On Dec 31, , A.S. Ducloy-Bouthors and others published Thalassémie } Welke behandeling van een anemie bij ß-thalassemie minor heeft de voorkeur. thalassemie NAO, thalassemieën, anemie; thalassemie, hemoglobinopathie; met thalassemie, leptocytose; hereditair, thalassemie; aandoening hemoglobine, . Relatie van de determinant met ongezondheid Bloedarmoede (anemie) ( bijvoorbeeld sikkelcellen* en thalassemie*) en intoxicaties (bijvoorbeeld lood).
|Published (Last):||20 May 2013|
|PDF File Size:||14.97 Mb|
|ePub File Size:||12.75 Mb|
|Price:||Free* [*Free Regsitration Required]|
Started inthis collection now contains tjalassemie topic pages divided into a tree of fhalassemie specialty books and chapters. Check this box if you wish to receive a copy of your message. Beta-thalassemia BT major is a severe early-onset form of BT see this term characterized by severe anemia requiring regular red blood cell transfusions. Another, mobile version is also available which should function on both newer and older web browsers.
Both disease-causing alleles must be identified before prenatal testing can be performed. Pharmacology Chapter related topics Hydroxyurea.
Treatments include blood transfusions and treatment to remove excess iron from the body. Hemoglobin is a protein that carries oxygen to the body.
Prognosis Patients who do not receive regular transfusions and iron chelation amnie die before the 2nd or 3rd decade whereas survival is higher in regularly transfused and chelated patients. Hemoglobin is a protein that carries oxygen to the body. Please Contact Me as you run across problems with any of these versions on the website. Males and females affected equally Prevalence of Thalassemia World wide: Only comments written in English can be processed.
A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. The prevalence of this form is not known. Only comments seeking to improve the quality and accuracy of information on the Orphanet website abmie accepted. Thalassemias thlaassemie be mild or severe. Prenatal diagnosis is possible by amniocentesis. You are currently viewing the original ‘fpnotebook.
Anémie Thalassémie by Siyobana Buzamlak on Prezi
Anemia results from this abnormal hemoglobin formation. Mutations causing BT major are homozygous or compound heterozygous. Some people have no symptoms or mild anemia. Doctors diagnose thalassemias using blood tests. Patients who do not receive regular transfusions and iron chelation usually die before the 2nd or 3rd decade whereas survival is higher in regularly transfused and chelated patients.
Feeding problems, diarrhea, irritability, recurrent bouts of fever, and progressive enlargement of the abdomen caused by splenomegaly and hepatomegaly may occur.
Although access to this page is not restricted, the information found here is intended for use by medical providers.
Blood analysis shows reduced Hb levels 50 12 Differential diagnosis Differential diagnosis is usually simple but may include genetic sideroblastic anemias, congenital dyserythropoietic anemias, and other conditions with high levels of HbF such as juvenile myelomonocytic leukemia and aplastic anemias; see these terms.
In some severe cases, you may need a bone marrow transplant. Splenectomy may be required. If you have mild symptoms or no symptoms, you may not need treatment. Recently a first patient was successfully treated with gene therapy.
Content is updated monthly with systematic literature reviews and conferences. Genetic counseling provides information for patients and at-risk couples i. That leads to anemia. An inherited blood disorder characterized by a decreased synthesis of one of the polypeptide chains that thalasseime hemoglobin. Transmission is autosomal recessive.
People with it may have severe anemia, slowed growth and delayed puberty, and thhalassemie with the spleen, liver, heart, or bones. National Heart, Lung, and Blood Institute. The documents contained in this web site are presented for information purposes only.
Back Links pages that link to this page. Management should also include treatment of iron overload-related complications growth deficiency, delayed puberty, hypogonadism, hypopara- and hypothyroidism, diabetes, and osteoporosis.
The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.
Orphanet: Beta tha
If you have one, your body makes fewer thalassdmie red blood cells and less hemoglobin. A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. Related links to external sites from Bing. Additional information Further information on this disease Classification s 3 Gene s 1 Clinical signs and symptoms Other website s 0.
Diagnosis is suspected in infants younger than 2 years of age with severe microcytic anemia, mild jaundice and hepatosplenomegaly. National Heart, Lung, and Blood Institute. BT is caused by point mutations or, more rarely, deletions in the HBB gene 11p These images are a random sampling from a Bing search on the term “Thalassemia.
Management and treatment Treatment is based on lifelong transfusions to correct anemia, suppress erythropoiesis, and inhibition of gastrointestinal iron absorption, which tgalassemie in non-transfused patients due to increased, although ineffective, erythropoiesis.
Other complications are hypersplenism, venous thrombosis and osteoporosis. Hematology and Oncology Chapters. Patients should address specific medical concerns with their physicians.