Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el. English: Tumors of the salivary glands represent % of head and neck neoplasms. Mucoepidermoid carcinoma (MEC) is the most common epithelial.

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The majority of MECs 27 cases were classified as low grade of malignancy. However, many studies found that benign and malignant salivary gland neoplasms with evidence of myoepithelial lineage do not overexpress c-erbB-2 protein which support the view that this growth receptor is not involved in their pathogenesis Rosa et al. The Mucoepidrmoide method was used to plot survival curves with the log rank test for analysis of cumulative survival rates.

Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. Although the latter may present myoepitelial derivation, carcinoma ex pleomorphic adenoma probably adquired a particular biological behavior in the longstanding process of malignant transformation.

Carcinoma mucoepidermoide

The broad age range observed in our series supports that reported in literature. Seifert G, Sobin LH. There were no statistically significant differences for any analyzed variable affecting OS curves.

Unlike other studies that used this same grading system, 4,13 the results demonstrate muciepidermoide balance in distribution among the three tumor grades subtypes. MEC is the most common malignancy of salivary glands and presents a diverse age distribution Auclair et al; Lopes et al.

Carcinoma mucoepidermoide

University of Sao Paulo, Brazil. Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: Mucoepidermoid tumors of the salivary glands. Two oral pathologists reviewed all cases to histopathologically classify these tumors according to the protocol published by Brandwein and others 10which classifies tumors into low Grade Iintermediate Grade II or high Grade III grades.


Rare expression of the c-erbB-2 oncoprotein in salivary gland carcinkma Although the significance of this cytoplasmic staining remains unknown, Cheng et al. Evaluation of the immunohistochemical staining.

Thus, the aim of this study was to analyze a series of intraoral MEC for expression of the c-erbB-2 oncoprotein and its possible association with the clinicopathologic features of the sample. In our series, patients demonstrated an earlier average age of occurrence, with a peak of incidence in the third and fourth decades of life, whereas previous studies described a prevalence in fifth and sixth decades of life Auclair et al.

Its intracellular component has a tyrosine kinase activity, whereas the extracellular domain may act as a growth factor receptor because of its considerable homology with epidemial growth factor receptor Nguyen et al. This provides further support to the existence of distinct molecular mechanisms in salivary gland carcinogenesis associated with the overexpression of c-erbB The medical and surgical records of all cases were reviewed for clinicopathological factors, such as salivaless, gender, primary tumor location, tumor size, clinical stage, histological grade, treatment, compromised surgical margins, tumor recurrence, metastasis, disease-free survival DFS and overall survival OS.

Blocking of endogenous avidin-botin activity in immunohistochemistry. However, other studies reported a rare expression of c-erbB-2 on these tumors Kernohan et al. R; Milanezi, E; Olson, S. Evaluation and application of grading criteria in cases. The use of skim milk as an economical and effective substitute for commercial biotin solutions.

Data regarding the positivity for c-erbB-2 on glanvulas gland tumors are very variable. Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell proliferation in malignant salivary gland tumours.

Mucoepidermoid carcinoma of intraoral salivary glands. The three-level grading system commonly used by pathologists for MEC classification mainly considers the relative proportion of cell types epidermoid, intermediate and mucinous cellstheir respective degrees of atypia and growth patterns cystic, solid, carcinoka infiltrativetogether with neural and vascular invasion.


Mucoepidermoid carcinoma of glandulqs salivary glands: Histopathologic grading of salivary gland neoplasms. Sinonasal and maxillary tumors were not included in this study as intraoral salivary gland tumors since that in these locations mucoepidermoid carcinoma presents different origin rather than glandular Ellis et al.

This antibody although less sensitive than the polyclonal antibody glanndulas in other reports Lopes et al. All positive cases also expressed cytoplasmic staining. Users should refer to the original published version of the material for the full abstract.

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Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica

Data concerning survival recurrence and metastasis were evaluated. Complementary studies to compare carbohydrates of the normal salivary glands must be carried out because subtle alterations in tumor cells glycosylation can influence their biological behavior. Remote access to EBSCO’s databases is permitted to patrons of subscribing institutions accessing from remote locations for personal, non-commercial use.

The ki67 expression was important in high grade tumors.

Oral Oncol, 41 1: Despite the small sample studied our results demonstrated no association among c-erbB-2 expression and demographic or histological glanvulas of MEC. Pattern of parotid gland tumors on Crete, Greece: Most of the studies show that the palate is the most common site of ocurrence Lopes et al.

The disease-free interval for recurrences and metastases ranged from 22 to months and 22 to months, respectively.